Description
A proton pump inhibitor; inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles (IC50 = 6.8 µM); reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg); inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg); inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg)